Ankylosing Spondylitis: Understanding the Chronic Spine Condition
Ankylosing spondylitis (AS) is a chronic, inflammatory autoimmune disease that primarily affects the spine and sacroiliac joints, where the spine meets the pelvis. Over time, the inflammation can lead to the fusion of vertebrae, resulting in reduced flexibility, a hunched posture, and chronic pain. AS belongs to a group of diseases known as spondyloarthropathies and typically begins in early adulthood, more commonly in men than women. Ankylosing Spondylitis: Understanding the Chronic Spine Condition What Causes Ankylosing Spondylitis? The exact cause of ankylosing spondylitis is unknown, but both genetic and environmental factors play a role. A significant number of people with AS carry a gene called HLA-B27, which is associated with increased risk of developing the condition. However, not everyone with the gene develops AS, indicating that other factors, such as infections or immune system dysregulation, may be involved. Symptoms AS symptoms usually develop gradually and may inc...